Name: | Trifluoroacetic Acid |
Synonym: | R3, TRIFLUOROACETIC ACID; R4A, TRIFLUOROACETIC ACID;
RARECHEM AL BO 0421;PERFLUOROACETIC ACID; TFA; TRIFLUOROACETIC ACID; TRIFLUOROACETLC ACID; WASH BUFFER |
CAS: | 76- 05-1 |
Formula: | C2HF3O2 |
Appearance: | Colorless transparent liquid |
EINECS: | 200-929-3 |
HS Code: | 2915900090 |
Trifluoroacetic acid is an important organic synthetic reagent, from which various fluorine-containing compounds, pesticides and dyes can be synthesized. Trifluoroacetic acid is also a catalyst for esterification and condensation. It can also be used as a protective agent for hydroxyl and amino groups, and can be used for the synthesis of sugar and polypeptide.
Trifluoroacetic acid has many preparation routes:
1.It is obtained by oxidation of 3,3,3- trifluoropropene with potassium permanganate.
2.It is obtained by electrochemical fluorination of acetic acid (or acetyl chloride and acetic anhydride) with hydrofluoric acid and sodium fluoride, and then hydrolysis.
3.It is obtained by oxidation of 1,1,1- trifluoro -2,3,3- trichloropropene by potassium permanganate. This raw material can be prepared by Swarts fluorination of hexachloropropene.
4.It is prepared by oxidation of 2,3- dichlorohexafluoro -2- butene.
5.Trifluoroacetonitrile is generated by the reaction between trichloroacetonitrile and hydrogen fluoride, and then hydrolyzed.
6.It is obtained by oxidation of trifluorotoluene.
Trifluoroacetic acid is mainly used in the production of new pesticides, medicines and dyes, and also has great application and development potential in materials, solvents and other fields.